Effects of N-Carboxyacyl Phosphatidylethanolamine Deriva- tives on Physicochemical Properties of Liposomes
نویسندگان
چکیده
The effects of carboxyacyl phosphatidylethanolamine derivatives (CA-PE) on the physicochemical properties of liposomes were examined from standpoints of zeta-potential, agglutination, phase transition temperature, microviscosity and micropolarity. Absolute zeta-potential of liposomes containing Succinyl-PE or Glutaryl-PE exceeded that of those containing Dodecanyl-PE. The addition of Succinyl-PE or Glutaryl-PE to liposomes resulted in even less microviscosity close to membrane surfaces of liposomes, compared to Dodecanyl-PE. The exposure of hydrophilic moiety of Succinyl-PE or Glutaryl-PE on liposome surfaces and orientation of carboxyacyl groups of Dodecanyl-PE differing from that of other CA-PE may be explanation for these findings. Avidin-biotin reaction-induced agglutination of liposomes containing Succinyl-PE or Glutaryl-PE was found to be reduced, possibly due to a steric barrier of exposed hydrophilic groups of Succinyl-PE or Glutaryl-PE on liposome surfaces.
منابع مشابه
Study of anti-cancer effects of Curcumin; formulation of Curcumin-loaded nano carrier and its toxicity effect on MCF-7 Cell line.
Introdution: Nanotechnology introduced new methods to chemotherapy drugs delivery into cancer cells to reduce the side effect of drugs it increases the quality of cancer treatment and reduces the side effects of chemotherapy. . In this study, different lipid formulations of nucliposomes containing curcumin was prepared by thin-layer method and evaluated for chemical-physical evaluation on MCF-7...
متن کاملThe Action of Hydrazine and Some of Its Deriva- Tives in Producing Liver Injury as Measured by the Effect on Levulose Tolerance
متن کامل
Modification of Guanine Derivatives by Reduced 2-Nitroimidazoles1
Misonidazole, after reduction to the hydroxylamine deriva tive, was found to react with guanosine in aqueous solution at pH 7. The guanosine product was isolated and was assigned a structure having a new 5-membered ring with a —CHOHCHOH-linkage between the N-1 and N-2 positions of guanine. Removal of the sugar residue from the guanosine product by acid hydrolysis resulted in the corresponding...
متن کاملSynthesis of Metformin Hydrochloride nanoliposomes: Evaluation of physicochemical characteristics and release kinetics
Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...
متن کاملSynthesis of Metformin Hydrochloride nanoliposomes: Evaluation of physicochemical characteristics and release kinetics
Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009